URINARY NGF IN OAB AFTERANTIMUSCARINICS TREATMENTS
H. YOON1, Y. PARK 2,W. CHUNG 1;
1Urology, Ewha Womans Univ.Sch. of Med., Seoul, Korea, Republic of, 2Ewha WomansUniv. Sch. of Med., seoul, Korea, Republic of.
Introduction: Nerve growthfactor (NGF) is a neuropeptide involved in the proliferation andregulation of growth, and survival of certain target neurons. It iseasily identified in urine. In our previous studies, urinary NGF wasmore expressed in several conditions with bladderirritation.
Objective: In this study, we investigated thechanges of urinary NGF expression in overactive bladder (OAB) patientdepending on anticholinergics treatments responses.
Methods:Subjects were divided into two groups; healthy female without noknown urologic problems as a control group (n=52, 50.46±9.98(34~77)years old), and OAB female patients as an OAB group (n=50,53.2±15.88(24~77) years old). In OAB group, urine sample wascollected from catheterized urine before and two months after theantimuscarinic treatment. Collected urine was centrifuged at 5000rpmthen NGF level in the supernatant was measured by ELISAmethod.
Results: Urinary NGFs were different withstatistical significance (pre-treatment OAB 1.57±0.25(1.1~2.19)ng/ml;post-treatment OAB 1.29±0.23(0.9~1.7)ng/ml; control0.59±0.23(0.06~0.99)ng/ml, p=0.0000, ANOVA). In OAB group, urinaryNGF was elevated compared with control group (p=0.000, pairedt-test), and it was significantly decreased with antimuscarnicstreatment (p=0.0002, paired t-test). Presence of lower abdominaldiscomfort, pain, frequency, nocturia, urgency, and urinaryincontinence did not show any significant correlations betweenurinary NGF expressions.
Conclusions: Urinary NGF iselevated in OAB compared with normal bladder. Anticholinergicstreatments lower the urinary NGF. Urinary NGF changes combined withantimuscarinic treatment may represent the treatment responsibilityof OAB. This may provide a prognostic factor of medical treatment inOAB for deciding next step of treatment.