DOES SEVERITY OF OAB AFFECT THEOUTCOME OF CONSERVATIVE THERAPY?
A. OBLOZA1, R. C. TEO2, C. MAYNE 3, K. LANE 1, D. G.TINCELLO 4;
1Leicester Gen. Hosp. NHSTrust, Leicester, United Kingdom, 2Univ. Hosp. Leicester,Leicester, United Kingdom, 3Urogynaecology, Univ. Hosp. ofLeicester, Leicester, United Kingdom, 4Univ. of Leicester,Leicester, United Kingdom.
Introduction: Conservativetreatments and drug therapy are both effective treatments foroveractive bladder (1, 2). However, there is a lack of evidence onwhether treatment outcome is affected by severity of the conditionbefore treatment.
Objective: To identify factors that maypredict the success or failure of conservative management for OABsymptoms.
Methods: review of outcomes for OAB patients in atertiary centre. UK OAB-q SF, IQIQ-UI SF and bladder diaries wereused to record severity of symptoms. Patients were subjected to astandardised therapy: lifestyle advice, supervised PFT and bladdertraining. Therapy success or failure was assessed by Patient GlobalImpression of Improvement questionnaire. Non-parametric statisticaltests and ROC curves were used to analyse the data.
Results:Fifty cases were reviewed. Outcomes were divided into: success andfailure groups. There were significant differences between the groupsin baseline OAB and ICIQ-UI questionnaires and some bladder diarydata (Table 1).
ROC curve analysis showed these factors to havereasonable test performance statistics. However, binary logisticregression on patient reported outcome showed that only OAB HRQLscore was independently associated with outcome (OR 1.104, 95% CI1.046, 1.166. The optimal cut off point for this score gave asensitivity of 95% and specificity of 73%.
Conclusions:These results demonstrate baseline symptom severity can predictpatient reported treatment outcomes. From these data, only OAB HRQOLscores from the oab-q were independent predictors of outcome.Immediate triage to direct initial interventions warrantsinvestigation.
References: 1. Cochrane Database ofSystematic Reviews 2014, Issue 5. Art. No.: CD005654.