abstract142 - IS METABOLIC SYNDROME INFLUENCING FACTOR IN FEMALE LOWER URINARY TRACT SYMPTOMS?
IS METABOLIC SYNDROME INFLUENCINGFACTOR IN FEMALE LOWER URINARY TRACT SYMPTOMS?
H. YOON1, Y. PARK 2,W. CHUNG 1;
1Urology, Ewha Womans Univ.Sch. of Med., Seoul, Korea, Republic of, 2Urology, EwhaWomans Univ. Seoul Seonam Hosp., Seoul, Korea, Republic of.
Introduction: Increasingevidence from clinical and epidemiological studies has shownassociations between lower urinary tract symptoms (LUTS) and majorchronic illnesses, such as heart disease and diabetes. Reports showsignificant correlation between markers of metabolic syndrome andLUTS in men. However, metabolic syndrome also takes major clinicalconcern in women. Besides, population of incontinence and/or OAB isnot small in aged women.
Objective: We attempted to examinethe correlation between metabolic syndrome and lower urinary tractsymptoms, overactive bladder in particular in female.
Methods:A total of 384 female patients participating in a health examinationunderwent completed the International Prostate Symptoms Score (IPSS)questionnaire and the Overactive Bladder Questionnaire Short Form(OABq-SF) symptom bother scale. Metabolic syndrome was defined byusing the National Cholesterol Education Program Adult TreatmentPanel III criteria announced in 2001. We analyzed differences inlower urinary tract symptoms in accordance with distinctions ofaccording to the presence of metabolic syndrome and constitutionalthe component elements of metabolic syndrome.
Results: Meanage was 49.7±5.1 years old. Among all patients, the number ofpatients with metabolic syndrome was 33 females (8.6%). Depending onthe presence or absence of metabolic syndrome, the IPSS and OABq-SFscores showed significant differences (p<0.05). Among variousfactors, age, HDL cholesterol, and triglyceride showed significantcorrelation with LUTS consisting OAB.
Conclusions: Certainfactors of metabolic syndrome have significant correlations in LUTSin women. Although aging is the well- known risk factor in OAB, thisstudy supports that presence of metabolic syndrome would be thesignificant risk factor in female OAB. More and larger well-designedstudies on the effects of metabolic syndrome in managing OAB infemale should be required. Meanwhile, early detection and propermanagement of metabolic syndrome not only managing symptoms of OABwill provide better clinical outcomes.
References: 1.Metabolic syndrome in female patients with overactive bladder.Urology. 2012;79(1):72-5.2. Sensory dysfunction of bladder mucosa andbladder oversensitivity in a rat model of metabolic syndrome. PLoSOne. 2012;7(9):e45578.3. Evaluation of factors influencing thenatural history of nocturia in elderly subjects: results of theFujiwara-kyo Study. J Urol. 2013;189(3):980-6.