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abstract

340 - ELASTIN GENETIC POINT MUTATION AND THE RISK FOR PELVIC ORGAN PROLAPSE

340

ELASTIN GENETIC POINT MUTATION ANDTHE RISK FOR PELVIC ORGAN PROLAPSE

N. HAYA 1, I. FEFERKORN1,F. FARES 2, N. AZZAM 2, A. ZILBERLICHT 1,R. AUSLENDER 1, Y. ABRAMOV 1;
1Obstetricsand Gynecology, Carmel Med. Ctr., Haifa, Israel, 2Facultyof Natural Sciences, Univ. of Haifa, Haifa, Israel.

Introduction: A missensemutation in the Elastin gene (g28197A > G) is associated with anincreased risk for inguinal hernias. Due to the sharedepidemiological and pathophysiological features between pelvic organprolapse (POP) and inguinal hernias, we hypothesized that a similarassociation exists between Elastin gene polymorphism andPOP.
Objective: To assess whether a missense mutation inthe Elastin gene is more prevalent in a population with advancedpelvic organ prolapse
Methods: Patients of Ashkenazi Jewishorigin with advanced (stage III-IV) POP (as assessed by POP-Q) andhealthy controls were compared for the presence of the Elastin geneg28197A > G missense mutation.
Results: The missensemutation in the Elastin gene was not found in either the study or thecontrol group.
Conclusions: The Elastin gene g28197A > Gmissense mutation was not found to be associated with an increasedrisk for POP.
References: 1. The ELN f gene exon 20 g28197A> G missense point mutation is present at a significantly higherfrequency in inguinal hernia patients than in non-herniated controls2. Patients with advanced pelvic organ prolapse have a higherprevalence of hiatal and inguinal hernias. This finding may beexplained by similar pathophysiological mechanisms shared by bothdisorders